Generic drug of the therapeutic class: Infectiology - Parasitology
Active ingredients: Doxycycline
Box of 28
Prophylactic treatment of traveler's malaria in endemic areas in case of resistance, contraindication or mefloquine intolerance.
Dosage DOXYPALU 50 mg Tablet Box of 28
The treatment will be started the day before departure, it will be continued for the duration of the risk of malnutrition and for 4 weeks after the return of the endemic area.
- Adult: 100 mg daily.
- Children over 8 years old:
. weight <40 kg : 50 mg daily.
. weight> 40 kg : 100 mg daily.
The tablets should be given in the middle of a meal with a glass of water (100 ml) and at least one hour before bedtime. The tablet can also be diluted in a glass of water (100 ml) before absorption and at least 1 hour before bedtime. In this case, shake well the resulting suspension to swallow the entire drug.
This medicine MUST NEVER BE USED in the following situations:
- in case of allergy to antibiotics of the family of tetracyclines,
- in children under 8 years of age due to the risk of permanent staining of teeth and hypoplasia of dental enamel,
- in the pregnant woman from the 2nd trimester of the pregnancy because of the risk of anomaly of the dental bud or dental dyschromia in the child,
- in association with retinoids by general route (see interactions).
NOT RECOMMENDED :
This medicine should NOT be used during breastfeeding.
Doxypalu side effects
Skin and subcutaneous tissue disorders
Photosensitivity reactions, rash, very rare cases of erythroderma.
Renal and urinary disorders
Extra-renal hyperazotemia related to anti-anabolic effect and may be increased by association with diuretics has been reported with tetracyclines. This hyperazotemia has not been observed to date with doxycycline.
Immune system disorders
Allergic reactions (urticaria, rash, pruritus, angioedema, anaphylactic reaction, rheumatoid purpura, pericarditis, exacerbation of preexisting lupus erythematosus).
Nervous system disorders
Benign intracranial hypertension in adults has been reported during treatment with tetracyclines. Therefore, treatment should be discontinued if an increase in intracranial tension is suspected or observed during doxycycline treatment.
Dental dyschromia or enamel hypoplasia when administered in children under 8 years of age.
Digestive disorders (nausea, epigastralgia, diarrhea, anorexia, glossitis, enterocolitis, anal or genital candidiasis).
Possible occurrence of dysphagia, oesophagitis, oesophageal ulcerations, favored by lying down and / or with a small amount of water.
Blood and lymphatic system disorders
Cases of haematological disorders have been described during treatment with tetracyclines (haemolytic anemia, thrombocytopenia, neutropenia, eosinophilia).