Medicinal Products


Generic drug of Vibramycin N
Therapeutic class: Dermatology
Active ingredients: Doxycycline
laboratory: Sandoz

Coated tablet
Box of 15
All forms


They derive from both the antibacterial activity and the pharmacokinetic properties of doxycycline. They take into account both the situation of this antibiotic in the range of antibacterial products currently available and up-to-date knowledge of the resistance of bacterial species.
They are limited to the following infections:
- brucellosis,
- pasteurelloses,
- Chlamydiae pulmonary, genitourinary and ophthalmic infections,
- pulmonary infections, genitourinary mycoplasma,
- Rickettsioses,
- Coxiella burnetii (Q fever),
- gonococcal,
- ENT and bronchopulmonary infections with Haemophilus influenzae, in particular acute exacerbations of chronic bronchitis,
- treponemes, (in syphilis, tetracyclines are indicated only in case of allergy to beta-lactams),
- spirochetes (Lyme disease, leptospirosis),
- cholera,
- medium and severe inflammatory acne and inflammatory component of mixed acnes.
Special situations:
Post-exposure prophylaxis and curative treatment of anthrax.
Official recommendations concerning the appropriate use of antibacterials should be taken into account.
- sensitive species:
. Gram-positive aerobes: Bacillus spp, Bacillus anthracis, Enterococci, Staphylococcus meti-S, Staphylococcus meti-R, Streptococcus A, Streptococcus B, Streptococcus pneumoniae .
. Gram - negative aerobes: Branhamella catarrhalis, Brucella, Escherichia coli, Haemophilus influenzae, Klebsiella, Neisseria gonorrhoeae, Pasteurella, Vibrio cholerae .
. anaerobes: Propionibacterium acnes .
. others: Borrelia burgdorferi, Chlamydia, Coxiella burnetii, Leptospira, Mycoplasma pneumoniae, Rickettsia, Treponema pallidum, Ureaplasma urealyticum .

Dosage DOXYCYCLINE GNR 100 mg Film-coated tablet Box of 15

- Adults:
. subjects weighing more than 60 kg :
200 mg a day in one shot.
. subjects of weight less than 60 kg :
200 mg the first day.
100 mg the following days in one take.
Special cases :
- acute gonorrhea :
. male adults:
. 300 mg on day 1 (twice taken) followed by 200 mg daily for 2 to 4 days,
. or a 500 mg minute treatment or 2 doses of 300 mg given 1 hour apart.
. adult females:
200 mg a day.
- primary and secondary syphilis :
300 mg daily in 3 doses for at least 10 days.
- uncomplicated urethritis, endocervicitis, proctitis due to Chlamydia trachomatis :
200 mg daily for at least 10 days.
- acne :
100 mg daily for at least 3 months. In some cases, a half-dose treatment may be used.
Special situations:
Anthrax disease: post-exposure prophylaxis and curative treatment of symptomatic people who can receive oral treatment either immediately or in combination with parenteral therapy: 200 mg daily in 2 doses.
The duration of treatment is 8 weeks when exposure to charcoal is proven.
- Children over 8 years old:
4 mg / kg / day.
Special situations:
Anthrax disease: post-exposure prophylaxis and curative treatment of symptomatic people who can receive oral treatment, either immediately or in combination with parenteral therapy: 4 mg / kg / day in two doses without exceeding the adult dosage (200 mg / day).
The duration of treatment is 8 weeks when exposure to charcoal is proven.
Administration mode :
Administer in the middle of a meal with a glass of water (100 ml) and at least one hour before bedtime.

Against indications

- Allergy to antibiotics of the family of tetracyclines.
- The use of this medication should be avoided in children under 8 years of age due to the risk of permanent staining of teeth and hypoplasia of tooth enamel.
- This drug is contraindicated from the second trimester of pregnancy: administration of cyclins in the second and third trimesters exposes the fetus to the risk of staining of the baby teeth. From the second trimester of pregnancy, administration of cyclins is contraindicated.
- Doxycycline - Retinoids (general route): see interactions.
Breast-feeding is not recommended when taking this medicine.

Side effects Doxycycline Gnr

- Dental dyschromia or enamel hypoplasia when administered in children under eight years of age.
- Digestive disorders (nausea, epigastralgia, diarrhea, anorexia, glossitis, enterocolitis, anogenital candidiasis).
Possible occurrence of dysphagia, oesophagitis, oesophageal ulcerations, favored by lying down and / or with a small amount of water.
- Allergic reactions (urticaria, rash, pruritus, angioedema, anaphylactic reaction, rheumatoid purpura, pericarditis, exacerbation of preexisting lupus erythematosus).
- Photosensitization reactions, rashes, very rare cases of erythroderma.
- Cases of haematological disorders have been described during treatment with tetracyclines (haemolytic anemia, thrombocytopenia, neutropenia, eosinophilia).
- Extrarenal hyperazotemia related to anti-anabolic effect and may be increased by association with diuretics has been reported with tetracyclines. This hyperazotemia has not been observed to date with doxycycline.

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