Medicinal Products

DOXY G 100 mg

Generic drug of the therapeutic class: Dermatology
Active ingredients: Doxycycline hyclate
laboratory: Elerte

Coated tablet
Box of 15
All forms


They derive from both the antibacterial activity and the pharmacokinetic properties of doxycycline. They take into account both the situation of this antibiotic in the range of antibacterial products currently available and up-to-date knowledge of the resistance of bacterial species.

They are limited to the following infections:

· Brucellosis,

· Pasteurellosis,

· Chlamydiae pulmonary, genitourinary and ophthalmic infections,

· Pulmonary infections, genitourinary mycoplasma,

· Rickettsioses,

· Coxiella burnetii (Q fever),

· Gonorrhea,

ENT and bronchopulmonary infections with Haemophilus influenzae, in particular acute exacerbations of chronic bronchitis,

· Treponemes, (in syphilis, tetracyclines are indicated only in case of allergy to beta-lactams),

· Spirochetes (Lyme disease, leptospirosis),

· Cholera,

· Medium and severe inflammatory acne and inflammatory component of mixed acnes,

· Aggressive periodontitis in addition to local mechanical treatment,

· Rosacea in its cutaneous or ocular manifestations,

· Prophylactic treatment of traveler's malaria in endemic areas in case of resistance, contraindication or mefloquine intolerance.

Special situations:

Post-exposure prophylaxis and curative treatment of anthrax.

Official recommendations concerning the appropriate use of antibacterials should be taken into account.

Dosage DOXY G 100 mg film-coated tablet Box of 15



· Subjects weighing more than 60 kg:
200 mg a day in one shot.

· Subjects weighing less than 60 kg:
200 mg the first day.
100 mg the following days in one take.

Special cases :

· Acute gonococcal infections

o Male adults:

§ 300 mg on day 1 (twice taken) followed by 200 mg daily for 2 to 4 days

§ or a 500 mg minute treatment or 2 doses of 300 mg given 1 hour apart.

o Female adults:

§ 200 mg daily

· Primary and secondary syphilis
300 mg daily in 3 doses for at least 10 days.

· Uncomplicated urethritis, endocervicitis, proctitis due to Chlamydia trachomatis

200 mg daily for at least 10 days.

· Acne
100 mg daily for at least 3 months. In some cases, a half-dose treatment may be used.

· Aggressive periodontitis in addition to local treatment: adult: 200 mg once daily, preferably in the morning during breakfast, for 14 days. The duration of treatment and dosage may be adapted in children.

Rosacea in its cutaneous or ocular manifestations:

Adult: 100 mg daily for 3 months. No clinical data is available beyond 3 months of treatment.

Malaria prophylaxis:

The treatment will be started the day before departure, it will be continued for the duration of the risk of malnutrition and for 4 weeks after the return of the endemic area.

· Adult: 100 mg daily.

· Child over 8 years old:

o weight <40 kg: 50 mg once a day,

o weight> 40 kg: 100 mg per day taken once.

Special situations:

Anthrax disease: post-exposure prophylaxis and curative treatment of symptomatic people who can receive oral treatment either immediately or in combination with parenteral therapy: 200 mg daily in 2 doses.

The duration of treatment is 8 weeks when exposure to charcoal is proven.

Children over 8 years old

· 4 mg / kg / day.

Special situations:

Anthrax disease: post-exposure prophylaxis and curative treatment of symptomatic people who can receive oral treatment, either immediately or in combination with parenteral therapy: 4 mg / kg / day in two doses without exceeding the adult dosage (200 mg / day).

The duration of treatment is 8 weeks when exposure to charcoal is proven.

Administration mode

Administer in the middle of a meal with a glass of water (100 ml) and at least one hour before bedtime.

Against indications

· Antibiotic allergy of the tetracycline family.

· Doxycycline - retinoid: see section Interactions with other medicinal products and other forms of interaction .

· Use of this medication should be avoided in children under eight years of age (because of the risk of permanent tooth staining and tooth enamel hypoplasia), as well as in pregnant or breastfeeding women (risk abnormal tooth bud or dental dyschromia in children).

· Pregnancy and breast-feeding: This medicine is contraindicated from the second trimester of pregnancy. Breast-feeding is not recommended when taking this medicine.

Side effects Doxy GE

Skin and subcutaneous tissue disorders

Photosensitivity reactions, rash, very rare cases of erythroderma.

Renal and urinary disorders

Extra-renal hyperazotemia related to anti-anabolic effect and may be increased by association with diuretics has been reported with tetracyclines. This hyperazotemia has not been observed to date with doxycycline.

Immune system disorders

Allergic reactions (urticaria, rash, pruritus, angioedema, anaphylactic reaction, rheumatoid purpura, pericarditis, exacerbation of preexisting lupus erythematosus).

Nervous system disorders

Benign intracranial hypertension in adults has been reported during treatment with tetracyclines. Therefore, treatment should be discontinued if an increase in intracranial tension is suspected or observed during doxycycline treatment.

Gastrointestinal disorders

Dental dyschromia or enamel hypoplasia when administered in children under 8 years of age.

Digestive disorders (nausea, epigastralgia, diarrhea, anorexia, glossitis, enterocolitis, anal or genital candidiasis).

Possible occurrence of dysphagia, oesophagitis, oesophageal ulcerations, favored by lying down and / or with a small amount of water.

Blood and lymphatic system disorders

Cases of haematological disorders have been described during treatment with tetracyclines (haemolytic anemia, thrombocytopenia, neutropenia, eosinophilia).

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