Medicinal Products


Generic drug of the therapeutic class: Analgesics
active ingredients: Paracetamol
laboratory: Sanofi-Aventis France

Box of 8
All forms


Symptomatic treatment of mild to moderate pain and / or febrile conditions.

Dosage DOLIPRANE ADULT 1000 mg suppository Box of 8

Administration mode :
Rectal way.
Warning: this presentation contains 1000 mg of paracetamol per unit: do not take 2 units at a time .
This presentation is reserved for adults and children weighing more than 50 kg (approximately 15 years).
- The usual unit dosage is 1 suppository 1000 mg per dose, to be renewed if necessary after 4 hours minimum.
- It is generally not necessary to exceed 3 g of paracetamol per day, or 3 suppositories per day. However, in case of more severe pain, the maximum dosage can be increased up to 4 g per day, or 4 suppositories per day. Always respect an interval of 4 hours between catches.
- In case of diarrhea, administration of the suppository is not recommended.
- Maximum recommended doses: See warnings.
Frequency of administration:
- Systematic catches prevent pain or fever oscillations:
in adults, they must be spaced at least 4 hours apart.
- In case of severe renal insufficiency (creatinine clearance less than 10 ml / min), the interval between two doses will be at least 8 hours.
Duration of administration:
Rectal administration should be as short as possible because of the risk of local toxicity.

Against indications

- Hypersensitivity to paracetamol or other constituents.
- Hepatocellular insufficiency.
- Recent antecedent of proctitis, anitis or rectorrhagia.
- In case of diarrhea, the suppository form is not suitable.

Adverse effects Doliprane Adult

- Few cases of hypersensitivity reactions such as anaphylactic shock, angioedema, erythema, urticaria, skin rash have been reported. Their occurrence requires the definitive discontinuation of this drug and related drugs.
- Very exceptional cases of thrombocytopenia, leukopenia and neutropenia have been reported.
Rectal and anal irritation

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