Medicinal Products


Generic Drug Therapeutic Class: Neurology-Psychiatry
Active ingredients: Dihydroergotamine
laboratory: Center Specialties Pharma

Injectable solution
in ampoule box of 2 ampoules of 1 mL
All forms


Treatment of migraine attack.

Dosage DIHYDROERGOTAMINE AMDIPHARM 1 mg / ml solution for injection in ampoules of 2 ampoules of 1 mL

Treatment of migraine attack.

Against indications

This drug MUST NEVER be prescribed in the following cases:

· Hypersensitivity to alkaloids of ergot or to any of the components.

· Conditions predisposed to angiospastic reactions: coronary insufficiency (particularly unstable or spastic angina), severe infectious conditions, shock, obliterative vascular disease, peripheral vascular diseases such as as Raynaud's syndrome, a history of transient ischemic attack or of cerebral pain or poorly controlled arterial hypertension.

· Temporal arteritis.

· Hemiplegic or basilar migraine.

· Severe hepatic insufficiency.

· In combination with triptans, antibiotics of the macrolide family (except spiramycin), antiproteases (eg ampraravir, atazanavir, fosamprenavir, indinavir, nelfinavir, ritonavir), reverse transcriptase inhibitors ( delavirdine, antiavirenz), voriconazole, triclabendazole, quinupristin-dalfopristine in combination, stiripentol, diltiazem, phenylpropanolamine (see section 4.5). See also Interactions with other medicinal products and other forms of interaction .

Adverse effects Dihydroergotamine Amdipharm

· Digestive disorders: nausea and vomiting unrelated to migraine, diarrhea, abdominal pain.

· Increased blood pressure.

· Dizzying sensation.

 · Hypersensitivity reaction: skin rash, facial edema, hives, dyspnea.

· End-stage paresthesia.

· In rare cases, vascular spasms may appear, especially at the lower extremities.

· Ischemia or, in rare cases, myocardial infarction.

After prolonged use of dihydroergotamine orally, isolated cases of fibrosis (including pleural and renalitoneal) have been reported after several years of treatment.

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