Generic drug of the therapeutic class: Analgesics
active ingredients: Ibuprofen
Box of 30
They come from the anti-inflammatory activity of ibuprofen, the importance of the manifestations of intolerance to which the drug results and its place in the range of anti-inflammatory products currently available.
They are limited, in adults (over 15 years), to:
· Long-term symptomatic treatment:
o chronic inflammatory rheumatism, including rheumatoid arthritis, ankylosing spondylitis or related syndromes such as Fiessinger Leroy-Reiter syndrome and psoriatic arthritis,
o some disabling and painful arthrosis;
· Short-term symptomatic treatment of acute attacks of:
o abarticular rheumatism such as scapulo-humeral periarthritis, tendonitis, bursitis,
o microcrystalline arthritis,
o back pain,
o acute post-traumatic benign conditions of the musculoskeletal system;
· Dysmenorrhea after etiological research;
· Symptomatic treatment of mild to moderate pain and / or febrile conditions.
Dosage ANTARENE Ge 400 mg Film-coated tablet Box of 30
Swallow the tablet without chewing it, with a large glass of water.
The occurrence of side effects can be minimized by using the lowest possible dose for the shortest duration of treatment required to relieve symptoms (see Warnings and Precautions section ).
Reserved for adults (over 15 years).
· Rheumatological indications:
o Attack treatment: 2 400 mg tablets, 3 times daily, or 2400 mg per day.
o Maintenance treatment: 1 400 mg tablet, 3 to 4 times daily, ie 1200 to 1600 mg per day.
· Dysmenorrhea: 1 400 mg tablet per dose, repeat if necessary, not to exceed 4 400 mg tablets per day (ie 1600 mg daily).
· Painful and / or febrile conditions: 1 tablet at 400 mg per dose, repeat if necessary, not to exceed 3 tablets at 400 mg per day (ie 1200 mg per day).
As age does not alter the kinetics of ibuprofen, the dosage should not need to be changed according to this parameter. However precautions must be taken (see section Warnings and precautions for use ).
Frequency and timing of administration:
The tablets are best taken during a meal.
Systematic catches prevent pain or fever oscillations. They should be spaced at least 6 hours.
This medicine is contraindicated in the following situations:
· Beyond 24 weeks of amenorrhea (5 months pregnant) (see section on Pregnancy and breastfeeding ),
· Hypersensitivity to ibuprofen or any of the excipients of the product,
· History of asthma triggered by ibuprofen or other substances of similar activity such as: other NSAIDs, acetylsalicylic acid,
· History of bleeding or digestive perforation during previous NSAID treatment,
· Gastrointestinal haemorrhage, cerebrovascular hemorrhage or other progressive haemorrhage,
· Progressive peptic ulcer, history of peptic ulcer or recurrent haemorrhage (2 or more episodes, or more, of haemorrhage or ulceration objectivized),
· Severe liver failure,
· Severe renal insufficiency,
· Severe heart failure,
· Systemic lupus erythematosus.
Side effects Antarene GE
Clinical studies and epidemiological data suggest that the use of ibuprofen, especially when used at high doses (2400 mg per day) over a long course of treatment, may be associated with a slight increase in the risk of arterial thrombotic event (eg, myocardial infarction or stroke) (see Warnings and Precautions for Use section ).
The most commonly observed side effects are gastrointestinal in nature. Peptic ulcers, perforation or gastrointestinal bleeding, sometimes fatal, can occur, especially in the elderly (see section Warnings and precautions for use ).
Nausea, vomiting, diarrhea, flatulence, constipation, dyspepsia, ulcerative stomatitis, abdominal pain, melena, hematemesis, exacerbation of rectocolitis or Crohn's disease (see Warnings and Precautions for Use section ) reported following administration of NSAIDs. Less frequently, gastritis has been observed.
Edema, hypertension and heart failure have been reported in combination with NSAID therapy.
Gastrointestinal disorders such as nausea, vomiting, gastralgia, dyspepsia, transit disorders, digestive ulcerations with or without haemorrhage, occult or non-occult haemorrhage have usually been reported. These are all the more frequent as the dosage used is high and the duration of treatment extended.
· Dermatological: rashes, rash, pruritus, edema, urticaria, aggravation of chronic urticaria.
· Respiratory: The onset of asthma attacks in some subjects may be related to an allergy to acetylsalicylic acid or a nonsteroidal anti-inflammatory drug (see section 4.3 ).
· General: anaphylactic shock, angioedema.
Very rarely bullous reactions (Stevens-Johnson syndrome, Lyell syndrome) have been observed.
Effects on the central nervous system
Ibuprofen may exceptionally be responsible for vertigo and headache.
· Some rare cases of visual disturbances have been reported,
· Oliguria, renal failure,
· The discovery of aseptic meningitis with ibuprofen should result in systemic lupus erythematosus or connective tissue disease.
Some biological modifications could be observed
· Hepatic: rarely elevated transaminases, exceptional cases of hepatitis.
· Haematological: agranulocytosis, haemolytic anemia.