Generic drug of the therapeutic class: Endocrinology
active ingredients: Demeclocycline
laboratory: Primus Lab Ltd

Indication

· Treatment of syndrome of inappropriate secretion of antidiuretic hormone (SIADH) more particularly of paraneoplastic origin with:

o chronic hyponatremia <125 mEq / l associated with inappropriate natriuresis

o and / or clinical signs related to hyponatremia,
and resistant to water restriction.

Note : it will be necessary before the prescription to eliminate the endocrine etiologies (adrenal insufficiencies and hypothyroidism, peripheral or of pituitary origin).

Dosage ALKONATREM 150 mg Capsule Box of 1 Bottle of 100

Dosage:

· Attack treatment: 900 - 1200 mg daily associated with moderate fluid restriction.
Duration: 8 to 10 days.

· Maintenance treatment: 600 mg daily (without water restriction).

· In the elderly: start immediately treatment with 600 mg per day.

In all cases, monitor serum sodium, blood urea, and serum creatinine.

Administration mode:

Oral way, apart from meals.

Against indications

· Antibiotic allergy of the tetracycline family.

· Renal insufficiency, liver failure.

· Child under 8 years old.

· Association with retinoids by the general route

· Pregnancy and breast feeding

Adverse effects Alkonatrem

· Dental dyschromia or enamel hypoplasia when administered in children under 8 years of age;

· Digestive disorders (diarrhea, nausea, epigastralgia);

· Allergic reactions (urticaria, rash, pruritus)

· Photosensitization reactions;

· Cases of haematological disorders have been described during treatment with tetracyclines (haemolytic anemia, thrombocytopenia, neutropenia, eosinophilia);

· Increases in blood urea and creatinine dependence and reversible doses upon discontinuation of treatment;

· Extrarenal hyperazotemia related to antianabolic effect has been reported with tetracyclines. This hyperazotemia may be increased by association with diuretics;

· Benign intracranial hypertension could be observed when using tetracyclines; it is manifested by headaches and disturbances of vision; in general, these signs disappear when the treatment is stopped.