Medicinal Products


Generic drug of the therapeutic class: Infectiology - Parasitology
active ingredients: Cefaclor
laboratory: Ethypharm

Extended release film-coated tablet
Box of 8
All forms


They arise from the antibacterial activity and pharmacokinetic characteristics of cefaclor. They take into account both the clinical studies that the drug has given and its place in the range of antibacterial products currently available.
They are limited to infections caused by sensitive germs when these infections allow oral antibiotic therapy and excluding meningeal locations, including:
- ENT infections: documented angina at beta-hemolytic streptococcus A,
- lower respiratory infections:
. superinfections of acute bronchitis,
. exacerbations of chronic bronchitis,
- uncomplicated urinary infections, except prostatitis and pyelonephritis.
Official recommendations concerning the appropriate use of antibacterials should be taken into account.

Dosage ALFATIL LP 500 mg Extended release film-coated tablet Box of 8

Oral way.
In the subject with normal renal function:
Therapeutic indications: Dosage. Duration of treatment .
- ENT infections: tonsillitis : 375 mg x 2 per day. 10 days.
- Superinfections of acute bronchitis : 375 mg x 2 per day. 7 to 10 days on average.
Exacerbations of chronic bronchitis : 500 mg x 2 daily or 750 mg x 2 daily. 7 to 10 days on average.
- Uncomplicated urinary tract infections, except prostatitis and pyelonephritis : 375 mg x 2 daily or 500 mg x 1 daily. 7 to 10 days on average.
Administration mode :
Swallow the tablets with a little water.
It is recommended that you take this medicine right after a meal or up to an hour later.

Against indications

This medication should never be used in case of allergy to cephalosporin antibiotics.

Alfatil LP side effects

- Allergic manifestations:
. Febrile reactions.
. Rashes, morbilliform rash, pruritus.
. Urticaria, Quincke's edema, and rarely anaphylactic shock. Anaphylactic reactions are more common in patients already sensitized to penicillin.
. Severe allergic reactions such as Stevens-Johnson syndrome and epidermal necrolysis have been reported in rare cases.
. Rare cases of serum sickness reactions have been reported. These are rashes most often urticarial, exceptionally erythema multiforme type, associated with arthralgia / arthritis, with or without fever, usually occurring during or after a second administration (or more) of drug. These symptoms, which have been described more frequently in young children, regress without sequelae a few days after stopping treatment. The effectiveness of antihistamines and corticosteroids has not been demonstrated. Short hospitalizations have sometimes been deemed necessary.
This symptomatology, which could be related to a hypersensitivity reaction, differs from the typical picture of serum sickness in that it is rarely related to lymphadenopathy and proteinuria and circulating immune complexes have not been found. in the rare cases where they were searched.
- Digestive manifestations:
. Diarrhea, nausea, vomiting, candidiasis.
. As with other antibiotics of this class, cases of pseudomembranous colitis have been reported with cefaclor.
- Liver manifestations:
Transient elevation of transaminases (ALT and ASAT) and alkaline phosphatases.
- Hematological manifestations:
Rare cases of neutropenia and agranulocytosis.
- Genital manifestations:
Vaginal pruritus or vaginitis, with or without candidiasis.
- Nephrotoxicity:
. Alterations in renal function have been observed with antibiotics in the same group, especially when combined with aminoglycosides and diuretics.
. Rare cases of reversible interstitial nephropathy have been reported. - As with any antibiotic, prolonged use of the drug may lead to a phenomenon of resistance of the germs involved.

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