Generic Drug Therapeutic Class: Diagnostic Products or Other Therapeutic Products
Active ingredients: Iodine human albumin
laboratory: Cis Bio International
Box of 4 5 ml single dose vials filled with 1.7 ml
This medicine is for diagnostic use only.
Measurement of plasma volume.
Determination of the turnover rate of plasma albumin.
Posology HUMAN ALBUMIN IODEE CIS BIO Injection solution Box of 4 5 ml single dose vials filled with 1.7 ml
In adults with a body mass of 50 kg to 70 kg, the recommended average activity is:
Measurement of plasma volume: 0.2 MBq
Plasma albumin turnover rate: 1 MBq
For the measurement of the plasma volume, blood samples are taken between the 10th and the 120th minute after the injection of the product. The radioactive concentrations measured on these samples make it possible to determine the initial radioactive concentration.
The use of stronger activities, such as tomoscintigraphy, is justified in certain clinical circumstances.
In children, the activity to be injected is a fraction of that recommended in adults, fraction obtained by applying the following formula:
Pediatric dose (MBq) = [Adult dose (MBq) x body mass of the child (kg)] / 70
Body mass is the best conversion parameter to be taken into account for determining the activity to be administered; nevertheless, in some cases it may be wise to use the body surface:
Pediatric dose (MBq) = [Adult dose (MBq) x body surface area of the child (m²)] / 1.73
To prevent a possible accumulation of free radioactive iodine in the thyroid resulting from the catabolism of labeled human albumin, potassium iodide (140 mg / day) should be administered 24 hours prior to injection. product and for a week after this, or potassium perchlorate (200 mg / day) 1 hour before the injection of the product and for 7 to 10 days after it.
Due to the presence of benzyl alcohol, this drug is contraindicated in premature infants and term newborns.
Side effects Human Albumin Iodee Cis Bio
Cases of fever and allergic reactions have been reported following the administration of radioiodinated human albumin. Adverse reactions include fever, dizziness, nausea, vomiting, tachycardia, hypotension and hives.
For any patient, exposure to ionizing radiation must be justified by the expected diagnostic benefit. The radioactivity administered should be such that the resulting irradiation is as low as possible, bearing in mind the need to obtain the required diagnosis.
Exposure to ionizing radiation can potentially induce cancer or develop inherited deficiencies. Experience shows that, for diagnostic tests in nuclear medicine, the frequency of these adverse effects is very low because of the low activities used.
For most nuclear medicine examinations, the effective dose (E) is less than 20 mSv.