Medicinal Products

ABBOTICINE 200 mg / 5 ml

Generic drug of the therapeutic class: Infectiology - Parasitology
Active ingredients: Erythromycin
laboratory: Amdipharm Limited

Granulate for oral suspension
Bottle of reconstituted syrup 60 ml
All forms


They arise from the antibacterial activity and pharmacokinetic characteristics of erythromycin. They take into account both the clinical studies that gave rise to this drug and its place in the range of antibacterial products currently available.

They are limited to severe infections due to germs defined as sensitive:

· Angina has been documented for beta-hemolytic streptococcus A, as an alternative to beta-lactam therapy, especially when it can not be used.

· Acute sinusitis. Given the microbiological profile of these infections, macrolides are indicated when beta-lactam therapy is not possible.

· Superinfections of acute bronchitis.

· Exacerbations of chronic bronchitis.

· Community pneumopathies in subjects:

o without risk factors,

o without signs of clinical severity,

o in the absence of clinical evidence suggestive of pneumococcal etiology.

In case of suspicion of atypical pneumopathy, macrolides are indicated whatever the gravity and the ground.

· Benign skin infections: impetigo, impetiginization of dermatoses, ecthyma, infectious dermo-hypodermitis (in particular, erysipelas), erythrasma, minor to moderate inflammatory acne and inflammatory component of mixed acnes, as an alternative to treatment with cyclins, when these can not be used.

· Stomatological infections.

· Non-gonococcal genital infections.

· Chemoprophylaxis of RAA relapses in case of beta-lactam allergy.

Official recommendations concerning the appropriate use of antibacterials should be taken into account.

Dosage ABBOTICINE 200 mg / 5 ml Granule for oral suspension 60 ml reconstituted syrup bottle


This medicine is suitable for infants and children up to 30 kg (about 10 years).

A measuring spoon (5 ml) contains 200 mg of erythromycin.

In children and infants: 30 to 50 mg / kg per day, ie 1 measuring spoon per 5 kg and 24 hours to be divided into 2 to 3 doses per day.

Reconstitute the oral suspension, adding the volume of water indicated on the vial. Taking before meals ensures the best serum levels.

Duration of treatment

The duration of treatment of angina is 10 days.

Against indications

This medicine MUST NEVER BE USED in the following situations:

- allergy to erythromycin,

- in association with :

- Bepridil

- cisapride

- the alkaloids of the ergot of rye vasoconstrictors

- methylergometrine

- Mizolastine

- the pimozide

- the sertindole

- simvastatin

(see Interactions with other drugs and other forms of interaction)

This drug is GENERALLY DISASSOSED in association with:

- Alfuzosin

- alkaloids of ergot dopaminergic rye

- the buspirone

- carbamazepine

- ciclosporin

- colchicine

- the disopyramide

- ebastine


- lumefantrine

- tacrolimus

- theophylline

- tolterodine

- triazolam

(see Interactions with other drugs and other forms of interaction)

Side effects Abboticine

Gastrointestinal manifestations: nausea, vomiting, gastralgia, diarrhea. Exceptional cases of pseudo-membranous colitis have been reported. Rare cases of pancreatitis, which can occur rapidly after the start of treatment, especially during high dose use or during overdose, have been reported.

Allergic skin manifestations; very rarely or exceptionally: erythema multiforme, Lyell's syndrome, Stevens Johnson syndrome.

Rare cases of liver injury with elevated alkaline phosphatase and / or transaminases have been reported with sometimes clinical manifestations (jaundice, fever) possibly associated with "acute abdominal pain". The appearance of clinical signs requires the immediate cessation of treatment.

Manifestations of ototoxicity in elderly patients with hepatic or renal impairment (see Warnings and special precautions for use).

Isolated cases of tinnitus have been reported.

Isolated cases of reversible hypoacusis have been reported mainly in patients with renal impairment and in patients treated with high dose erythromycin.

Cases of interstitial nephritis have been reported.

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